Gavi®
World´s first automated vitrification instrument
100 %
*Human blastocyst recovery rate
5,3 %
**Increase in clinical pregnancy rate
For standarised vitrification
with high-quality results
Vitrification is the most up to date and effective method of freezing oocytes and embryos, regardless of stage. Talk to embryologists about manual vitrification and they will readily agree that the process can be tedious and time-consuming. There is a long learning curve, skills need to be maintained and intense focus is required by the embryologist.
Gavi®, the world’s first automated vitrification instrument, was designed by embryologists who wanted better control over the variables involved in manual vitrification – temperature, embryo handling, cryoprotectant concentrations and balancing equilibration/vitrification timing. Their aim was stage specific, controlled vitrification performed in a standardised way every single time – and they were successful.
Explore Gavi®
Precision and Consistency in Embryo Vitrification and Storage
Created after four years of intensive development, Gavi® is the first technology to automate the critical equilibration step, helping to standardise the complex vitrification process.
Gavi® approaches vitrification in an entirely new way, helping to achieve consistent high-quality results every time.
Consistent and reproducible process
Unique Gavi® Pod
Precise equilibration process
High-quality results
A controlled, closed-system enviroment
Short learning curve
Gavi® helps you to achieve optimal vitrification conditions
There are many critical variables within the vitrification process that can impact embryos’ survival post-thawing – from achieving the right balance between the cryoprotectant concentrations and flow rates to reducing manual handling.
Automated solution dispensing
Gavi® Pod design
Control of exposure
Temperature control
Reduces the risk of cross-contamination
The Gavi® Family
Gavi® comes with a range of supplied accessories including:
Gavi® Operating Tray
Holds the Gavi® Medium Cartidge, Cassete and Tip & Seal Catridge.
Gavi® LN2 Bucket
Holds liquid nitrogen for the final stage of the vitrification process.
Gavi® Tweezers
For a secure grasp of the Gavi® Cassette when dunked into Gavi® LN2 Bucket.
Consumables used with Gavi®
Gavi® Tip & Seal Cartridge
Holds the disposable pipette tip and Pod lid seal.
Gavi® Medium Cartridge
Contains the Gems® vitrification solutions.
Gavi® Cassette
Holds up to four Pods at once, allowing you to vitrify four blastocysts or 8 oocyte/cleavage stage embryos simultaneously
Gavi® Pod
The Gavi Pod is a container with the capacity to hold two oocytes or zygote/cleavage stage embryos or one blastocyst stage embryo during the vitrification, storage and warming processes.
Accessories used with Gavi®
Gavi® Working station
Holds the Gavi® cassette within LN2 to facilitate the removal of single Pods for thawing.
Gavi® Storage Dividers
For use with cryogenic storage canisters, to provide orderly organisation of Cassette and Pods by patient. Available in round or rectangular form.
Greater consistency of results compared to manual methods.
To evaluate the potential improvements from a training and standardisation perspective, survival results across freeze scientists for the early stages of implementation at all Genea labs of Gavi® (2015-2017) and Cryotop® (2009-2010) were retrospectively analysed.
When comparing blastocyst survival, Gavi® reduces the variability of results among embryologists of different experience levels with a particular device.
Gavi® requires reduced technical skill compared to manual vitrification methods, with shorter learning curves, and a reduced time to achieve vitrification competency
Gavi® clinical outcomes:
Evidence lies in the results
Any implementation period gives an opportunity to analyse data and so we looked back. It became obvious how easy Gavi® was to learn and how quickly embryologists were able to achieve benchmark results compared to the manual method.
When analysing the early-stage implementation data for the two techniques we found using Gavi® there was a reduction in the variability of results between embryologists and the period between basic vitrification competency to aspirational competency was reduce.
Alpha Scientists in Reproductive Medicine (2012). The Alpha consensus meeting on cryopreservation key performance indicators and benchmarks: proceedings of an expert meeting. Reprod. Biomed. Online 25: 146-167.
Customer spotlight
GERI
I don’t find anything about working with the incubator bothersome. It’s user-friendly. Service is trouble-free. There’s no worry about it at all. It is beautifully maintained, has excellent displays and what helps us the most is it has remote access… that’s the thing we use to the max!
GERI
The moment we have the slightest problem we call them, they are always available, and if they can’t solve the problem by directing us over the phone on what we need to do, within half a day they come directly to our headquarters and come to see the incubator.
The engineers are all local. This is extremely positive because in case of problems, we call and they can solve the problems remotely or by immediately going on site.
Being able to see the time lapse images so clearly allows you to see the beginning developments of embryos, which is really crucial when deciding on which embryo to transfer. An embryo that does unusual first and second divisions do not correlate as highly with ongoing pregnancy rates than those that do. So when you’re trying to choose between a group of embryos having that seamless video from beginning of the embryo development after the fertilization is absolutely crucial in deciding which embryos should be used, in which order.
The Geri has an attractive, neat footprint and remote access from any computer which is very important for me when I am off-site and would like to check an embryo for a member of the team. The customer service is great. Our engineer is Lewis and he is available to help with all aspects of the machine. The team is knowledgeable and responsive. I would recommend Geri because as well as it being for time-lapse, it is also a very good humidified incubator, user friendly and easy to maintain.
We are very grateful for this incredible opportunity which will support us to carry out more innovative research projects focused on the impact of humidified environment on embryo culture systems and to incorporate time-lapse technology in our OPU-ICSI and SCNT equine cycles!
As a user of Geri and Gems Media, Genea Biomedx means proximity, trust and reliability. We have been together since 2016… and we will continue to be.
Gems
Our experience with other types of single-step media has not been as good as with the Geri Medium,
The way we can check the embryos, if an alarm goes off, to make sure that everything is as it should be… remotely. Because you have got your own user status hubs that allow you to see absolutely everything all the time. When you are at home at 10 o’clock at night and your alarms go off you need that. It gives me real peace of mind. It has changed, literally changed my life, in the last 18 months.
We’ve been using the Genea Biomedx Geri for 6 years now, it has been the mainstay of our culture system. I appreciate the fact that the system was designed from the ground up with constant input from embryologists. The interface is logical and very easy to use, and having six independent culture chamber modules, each with its own camera, makes the system extremely flexible. The design of the time-lapse dish is terrific, it is very easy to handle, and there are three large wells for rinsing and one large well with 16 micro-wells deep enough to keep embryos in place. The dish design also allows room for 4ml of oil overlay so that the culture media is better protected. The Genea Biomedx Geri is simply a great incubator- it has been a great addition to the laboratory.
Support documents
Gavi® User Manual – English
Gavi® User Manual – Spanish
Gavi® User Manual – Czech
Gavi® User Manual – German
Gavi® User Manual – French
Gavi® User Manual – Italian
Gavi® User Manual – Japanese
Gavi® User Manual – Korean
Gavi® User Manual – Norwegian
Gavi® User Manual – Swedish
Gavi® User Manual – Thai
Gavi® User Manual – Turkish
Gavi® User Manual – Vietnamese
Prior to use, always ensure that the most recent version of the online User Manual/Instructions for Use is being used.
Customers are advised to download and save the electronic versions of the User Manuals/Instructions for Use prior to use.
Hard copies of the User Manuals/Instructions for Use for any purchased Genea Biomedx product are available upon request and provided within 7 calendar days from receiving a request.
*Roy TK et al. Embryo vitrification using a novel semi-automated closed system yields in vitro outcomes equivalent to the manual Cryotop method. Human Reproduction 2014;29(11):2431-2438
**Alpha Scientists in Reproductive Medicine (2012). The Alpha consensus meeting on cryopreservation key performance indicators and benchmarks: proceedings of an expert meeting. Reprod. Biomed. Online 25: 146-167.